The Impact of Accutane on Your Body

During isotretinoin therapy, some patients may experience mild to moderate elevations in liver enzymes, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST). These changes are typically transient and often resolve even if treatment continues. In a study involving 13,772 patients, approximately 33% developed abnormal cholesterol levels, and about 50% had higher triglyceride levels during treatment. However, severe abnormalities were rare, and most returned to normal after stopping the medication. (ucsf.edu)

Effects on Blood Markers:

Isotretinoin can also affect lipid profiles and other blood parameters:

• Lipids: Elevations in triglycerides and low-density lipoprotein (LDL) cholesterol are common. A study found significant increases in serum triglycerides and cholesterol levels during treatment. (pubmed.ncbi.nlm.nih.gov)

• High-Density Lipoprotein (HDL): Some patients may experience a decrease in HDL cholesterol levels. In the same study, HDL levels decreased during treatment. (pubmed.ncbi.nlm.nih.gov)

• Other Blood Parameters: Elevations in gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) have been observed. However, these changes are usually mild and reversible upon discontinuation of the drug. (pubmed.ncbi.nlm.nih.gov)

Monitoring Recommendations

Given these potential changes, regular monitoring of liver enzymes and lipid profiles is recommended during isotretinoin therapy. Most mild elevations do not necessitate discontinuation of treatment. However, significant increases in liver enzymes or severe lipid abnormalities may require dose adjustments or cessation of the medication. (mdpi.com)

In summary, while isotretinoin can affect liver function and blood markers, these effects are generally mild, reversible, and manageable with appropriate monitoring.